“The Prevention and Therapy of Crohn’s Disease” identifies the neglected role played by the Anaerobic Progression in the creation of the permanent structural changes of the small bowel, strictures, bowel perforations, and loop-to-loop anastomosis observed with Crohn’s disease.
Once the immune-mediated interactions with Mycobacterium avium subspecies paratuberculosis cause the focal loss of mucosal integrity, the second mechanism of Crohn’s disease is potentially activated: the submucosal infection by the bacteria of the gastrointestinal tract and its conversion into the anaerobic progression.